The aims of this study were to explore the effects of the students-center teaching strategies on the course of early childhood special education. The action research were designed to solve the problems of teaching and learning through teaching reflection and adjustment. The results include: (1) problem-based learning can arouse students' willingness to participate in class and motivation effectively, (2) multiple teaching and assessment methods can promote students' willingness to learn and results effectively, (3) student learning outcomes can correspond to the course objectives. Finally, author has proposed specific recommendations for university teaching.