- 期刊
- OpenAccess
Current and Emerging Therapies for the Management of Bipolar Disorders
並列摘要
Bipolar disorder is a complex condition to treat because agents that may be effective for a specific phase may not be effective for other phases, or may even worsen the overall course of the illness. Over the last decade there has been an increase in research activity in the treatment of bipolar illness. There are now several agents that are well established for the treatment of acute mania (lithium, divalproex, carbamazepine, nearly all antipsychotics), acute bipolar depression (lamotrigine, quetiapine, olanzapine/fluoxetine combination), and relapse prevention (lithium, lamotrigine, divalproex, most second generation antipsychotics). There are also novel treatments that are being studied for all three phases. These include eslicarbazepine, cariprazine, MEM-1003, memantine, tamoxifen and pentazocine for acute mania; pramipexole, modafinil, armodafinil, divalproex, lurasidone, agomelatine, cariprazine, lisedexamfetamine, riluzole, RG-2417, bifeprunox, ropinirole, GSK1014802, and magnetic stimulation for bipolar depression; and asenapine, lurasidone, and cariprazine for relapse prevention. Additionally, there are accumulating data that antidepressants, particularly serotoninergic ones, are not particularly effective in acute bipolar depression and may worsen the course of the illness.
延伸閱讀
- Barbosa, I. G., Bauer, M. E., Vieira, R., & Teixeira, A. L. (2014). Cytokines in Bipolar Disorder: Paving the Way for Neuroprogression. Neural Plasticity, (2014), 82-90. https://doi.org/10.1155/2014/360481
- Theodore, R. S., Basco, M. R., & Biggan, J. R. (2012). Diagnostic Disagreements in Bipolar Disorder: The Role of Substance Abuse Comorbidities. Depression Research and Treatment, 2012(), 269-274. https://doi.org/10.1155/2012/435486
- Levy, B., & Manove, E. (2012). Functional Outcome in Bipolar Disorder: The Big Picture. Depression Research and Treatment, 2012(), 534-545. https://doi.org/10.1155/2012/949248
- Vieira, R. M., Frey, B. N., & Quevedo, A. C. A. (2015). Translational Research in Bipolar Disorders. Neural Plasticity, 2015(), 942-944-080. https://doi.org/10.1155/2015/576978
- Lopes, R., & Fernandes, L. (2012). Bipolar Disorder: Clinical Perspectives and Implications with Cognitive Dysfunction and Dementia. Depression Research and Treatment, 2012(), 148-158. https://doi.org/10.1155/2012/275957