- 期刊
Communication: Synthesis of a Novel Triphenyltin(IV) Derivative of 2-Mercaptonicotinic Acid with Potent Cytotoxicity in vitro
摘要
A novel triphenyltin(IV) derivative of 2-mercaptonicotinic acid (H_2mna) of formula {[(C_6H_5)_3Sn]_2(mna)‧[(CH_3)_2CO]} (1) has been synthesized and characterized by elemental analysis and ^1H, ^(13)C-NMR, and FT-IR spectroscopic techniques. The crystal structure of complex (1) has been determined by single crystal X-ray diffraction analysis at 173(1) K. Compound (1) contains two triphenyltin moieties linked by a doubly de-protonated 2-mercaptonicotinic acid (H_2mna). It is an example of a pentacoordinated Ph_3SnXY system with an axial-equatorial arrangement of the phenyl groups at Sn(1). Compound (1), exhibits potent, in vitro, cytotoxicity against sarcoma cancer cells (mesenchymal tissue) from the Wistar rat, polycyclic aromatic hydrocarbons (PAH, benzo[a]pyrene) carcinogenesis.
延伸閱讀
- Lin, Y. C. (2006). Investigation of Ethylene/Norbornene Copolymerization Using Cationic Methylpalladium(Ⅱ) Catalysts with Amino-Pyridine Ligands [doctoral dissertation, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2006.00282
- Kuo, H. M. (2010). Synthesis, Electrochemical, Electrochromic and Gas Permeation Properties of Novel Aromatic Polymers Containing Bis(triphenylamine)ether or Trimethyl-Substituted Triphenylamine Groups [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2010.10282
- 高敏昭（2009）。Synthesis and Electrochemical Studies of a Novel Triphenylamine Derivative〔碩士論文，國立暨南國際大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0020-0209200905003400
- Chandra, S., Parmar, S., & Kumar, Y. (2009). Synthesis, Spectroscopic, and Antimicrobial Studies on Bivalent Zinc and Mercury Complexes of 2-Formylpyridine Thiosemicarbazone. Bioinorganic Chemistry and Applications, 2009(), 17-22. https://doi.org/10.1155/2009/851316
- 林子軒（2013）。Synthesis and Opto-electrical Investigation of Hyperbranched Polythiophene Derivatives Containing Tetrachloroperylene Bisimide as Bridging Moiety〔碩士論文，國立交通大學〕。華藝線上圖書館。https://doi.org/10.6842/NCTU.2013.00569