Synthesis, Structure, Properties And Biological Behaviour Of The Complex [Ru^(IV) (H_2L) Cl_2]．2H_2O (H_4L= 1,2-Cyclohexanediamminetetraacetic Acid)

Rosario A. Vilaplana ； A. Castiñeiras ； Francisco González-Vílchez

《Bioinorganic Chemistry and Applications》 2004卷 (2004/12) Pp. 275-292

https://doi.org/10.1155/S1565363304000160

摘要

The octahedral complex [Ru(H_2cdta)CI_2]‧2H_2O contains Ru(IV) surrounded by two nitrogen atoms, N(1) and N(2), and two chloride ions cis to each other, all in the equatorial plane. Two oxygen atoms, O(11) and O(21) are located in trans axial octahedral positions. The complex shows remarkable in vitro and in vivo activity against different carcinomas. The highly water-soluble ruthenium complex [Ru(H_2L)CI_2]．2H_2O, in which H_4L is the sequestering ligand trans-l,2-cyclohexanediamminetetraacetic acid (cdta) has been synthesized, structurally characterized and its properties studied. The X-ray crystallographic study shows that the chelating coordinated ligand is tetradentate while the ruthenium environment is octahedral and slightly distorted, with two chloride anions coordinated in cis positions. Potentiometric, conductimetric and infrared studies confirm the presence of two free carboxylic groups, while electronic and voltammetric studies show that the central ion is Ru(IV). The testing of the cytotoxic activity of this complex against three different human cancer cell lines indicates that [Ru(H_2L)CI_2]．2H_2O shows a remarkable and selective antiproliferative effect against the human uterine neck carcinoma HeLa and the malign adenocarcinoma ADLD, showing only a discrete turnout cell inhibition activity against colon adenocarcinoma HT-29. The important antiprotiferative behaviour of complex against the human adenocarcinoma ADLD, indicates that [Ru(H_2L)CI_2]．2H_2O might be considered as potential antineoplastic compound.