- 期刊
- OpenAccess
Biomarkers of Dose and Effect of Inhaled Ozone in Resting versus Exercising Human Subjects: Comparison with Resting Rats
並列摘要
To determine the influence of exercise on pulmonary dose of inhaled pollutants, we compared biomarkers of inhaled ozone (_) dose and toxic effect between exercise levels in humans, and between humans and rats. Resting human subjects were exposed to labeled O_3 (^(18)O_3, 0.4 ppm, for 2 hours) and alveolar O_3 dose measured as the concentration of excess 18O in cells and extracellular material of nasal, bronchial, and bronchoalveolar lavage fluid (BALF). We related O_3 dose to effects (changes in BALF protein, LDH, IL-6, and antioxidant substances) measurable in the BALF. A parallel study of resting subjects examined lung function (FEV1) changes following O_3. Subjects exposed while resting had 18O concentrations in BALF cells that were 1/5th of those of exercising subjects and directly proportional to the amount of O_3 breathed during exposure. Quantitative measures of alveolar O_3 dose and toxicity that were observed previously in exercising subjects were greatly reduced or non-observable in O_3 exposed resting subjects. Resting rats and resting humans were found to have a similar alveolar O_3 dose.
延伸閱讀
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