- 期刊
- OpenAccess
Perchlorate Exposure is Associated with Oxidative Stress and Indicators of Serum Iron Homeostasis Among NHANES 2005-2008 Subjects
並列摘要
Perchlorate (ClO_4^-), an oxidizing agent, is a ubiquitous environmental pollutant. Several studies have investigated its thyroid hormone disrupting properties. Its associations with other biological measures are largely unknown. This study, combining 2005-2008 National Health and Nutrition Examination Surveys, investigated associations between urinary perchlorate and biomarkers of iron homeostasis, lipids, blood cell counts, and glucose metabolism. Healthy males (n = 3705), non-pregnant females (n = 2967), and pregnant females (n = 356), aged 12-59 years, were included in the linear regression models, which showed significant positive (+) and negative (-) associations for both males and non-pregnant females with serum uric acid (-), serum iron (-), RBC count (-), blood urea nitrogen (+), and lymphocyte count (+). Other significant associations were observed for either males or non-pregnant females. Among pregnant females, perchlorate was significantly associated with blood urea nitrogen (+) and serum iron (-). These associations may be indicators of perchlorate’s potential effect on several biological systems, which when considered in total, may implicate perturbation of iron homeostasis.
延伸閱讀
- 林聖敦、林柏松、王雪芳、蕭清娟（2005）。Effects of Isomaltooligosaccharide Chiffon Cake on Serum Biochemical Parameters, Constipation, and Fecal Putrefactive Metabolites in Hyperlipidemic Subjects。中華民國營養學會雜誌，30(2)，108-115。https://doi.org/10.6691/JCNS.200509_30(2).0006
- Napolitano, A., Murgatroyd, P. R., Finer, N., Hussey, E. K., Dobbins, R., O'Rahilly, S., & Nunez, D. J. R. (2011). Assessment of Acute and Chronic Pharmacological Effects on Energy Expenditure and Macronutrient Oxidation in Humans: Responses to Ephedrine. Journal of Obesity, 2011(), 97-104. https://doi.org/10.1155/2011/210484
- Lin, C. Y. (2011). Investigation of the Associations between Serum Perfluorinated Chemicals, Liver Enzymes, Thyroid Function, Glucose Homeostasis and Cardiovascular Risk Factors [doctoral dissertation, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2011.10341
- Zhu, G., Chen, C., Hu, B., Yuan, D., Chen, W., Wang, W., Su, J., Liu, Z., Jiao, K., Chen, X., Chen, W., Zhang, W., Sun, F., & Zhu, J. (2013). Dietary phosphorus intake and serum prostate-specific antigen in non-prostate cancer American adults: A secondary analysis of the National Health and Nutrition Examination Survey (NHANES), 2003-2010. Asia Pacific Journal of Clinical Nutrition, (), 1-21. https://doi.org/10.6133/apjcn.202005/PP.0008
- Zhu, G., Chen, C., Hu, B., Yuan, D., Chen, W., Wang, W., Su, J., Liu, Z., Jiao, K., Chen, X., Chen, W., Zhang, W., Sun, F., & Zhu, J. (2020). Dietary phosphorus intake and serum prostate-specific antigen in non-prostate cancer American adults: A secondary analysis of the National Health and Nutrition Examination Survey (NHANES), 2003-2010. Asia Pacific Journal of Clinical Nutrition, 29(2), 322-333. https://doi.org/10.6133/apjcn.202007_29(2).0015