- 期刊
Turnour necrosis factor stimulates endothelin-1 gene expression in cultured bovine endothelial cells
摘要
WE have studied the effect of human recombinant tumour necrosis factor-α (TNF-α) on gene expression and production of endothelin-1 in cultured bovine aortic endothelial cells. TNF-α (10 and 100 ng ml^(-1)) increased in a time dependent manner the preproendothelin-1 mRNA levels in respect to unstimulated endothelial cells. TNF-α induced endothelin-1 gene expression was associated with a parallel increase in the release of the corresponding peptide in the culture medium. These findings suggest that the enhanced synthesis and release of endothelin-1 occurring in conditions of increased generation of TNF, may act as a modulatory factor that counteracts the hypotensive effect and the excessive platelet aggregation and adhesion induced by TNF.
延伸閱讀
- 陳永銘, 林水龍, 姜文智, 蔡敦仁, & 謝博生 (2000). Signalling Pathways of Tumor Necrosis Factor-alpha-Stimulated Fractalkine Expression in Rat Mesangial Cells: Down-regulation by cAMP. Acta Nephrologica, 14(4), 250-250. https://www.airitilibrary.com/Article/Detail?DocID=10131671-200010-14-4-250-250-o
- Pruimboom, W. M., Verdoold, A., Tak, C. J. A. M., Dijk, A. P. M. V., Batenburg, M. V., Wilson, J. H. P., & Zijlstra, F. J. (1994). Changes in eicosanoid and tumour necrosis factor- production by rat peritoneal macrophages during carrageenin-induced peritonitis. Mediators of Inflammation, 1994(), 335-340. https://doi.org/10.1155/S0962935194000463
- Chou, Y. C. (2011). The regulatory mechanisms of the production of tumor necrosis factor-α and matrix metalloproteinase in human monocytic cells [doctoral dissertation, Taipei Medical University]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0007-1207201120520200
- Fritzenwanger, M., Meusel, K., Jung, C., Franz, M., Wang, Z., Foerster, M., & Figulla, H. R. (2009). Cardiotrophin-1 Induces Tumor Necrosis Factor α Synthesis in Human Peripheral Blood Mononuclear Cells. Mediators of Inflammation, 2009(), 319-325. https://doi.org/10.1155/2009/489802
- Fujita, H., Morita, I., & Murota, S. I. (1999). A possible involvement of ion transporter in tumor necrosis factor α and cycloheximide-induced apoptosis of endothelial cells. Mediators of Inflammation, 1999(), 211-218. https://doi.org/10.1080/09629359990379