Inhibitory effect of ferulic acid and isoferulic acid on the production of macrophage inflammatory protein-2 in response to respiratory syncytial virus infection in RAW264.7 cells

S. Sakai ； H. Kawamata ； T. Kogure ； N. Mantani ； K. Terasawa ； M. Umatake ； H. Ochiai

《Mediators of Inflammation》 1999卷 (1999/12) Pp. 173-175

https://doi.org/10.1080/09629359990513

摘要

WE investigated the effect of ferulic acid (FA) and isoferulic acid (IFA), which are the main active components of the rhizoma of Cimicifuga heracleifolia(CH), an anti-inflammatory drug used frequently in Japanese traditional medicine, on the production of macrophage inflammatory protein-2 (MIR-2) in a murine macrophage cell line, RAW264.7, in response to respiratory syncytial virus (RSV) infection. Following the exposure of cells to RSV for 20 h, the MIP-2 level in condition medium was increased to about 20 ng/ml, although this level in mock-infected cells was negligible. In the presence of either FA or IFA, RSV-infected cells reduced MIP-2 production in a dose-dependent manner. These data suggest that FA and IFA might be responsible, at least in part, for the anti-inflammatory drug effect of CH extract through the inhibition of MIP-2 production.

關鍵字

Respiratory syncitial virus ； Murine macrophage inflammatory protein-2 ； Ferulic and isoferulic acids ； RAW264.7 cells