- 期刊
The inhibitory effect of anti-allergic agent suplatast tosilate (IPD-1151T) on methacholine- and allergen-induced bronchoconstriction in sensitized mice
摘要
THE influence of an anti-allergic agent, suplatast tosilate (IPD-1151T; (± )-[2-[4-(3-ethoxy -2-hydroxy-propoxy )phenyl-carbamoyl]-ethyl] dimethylsulfonium p-toluenesulfonate) on allergic bronchoconstriction induced by allergen and methacholine (MCh) were examined in mice. BALB/c mice were sensitized by intraperitoneal injection of dinitrophenylatedkeyhole limpet hemocyanin (DNP-KLH) mixed with Al(OH)_3 (DNP-KLH). IPD-1151T was administered orally once a day for either 5 or 14 days in dose s of 10, 30 or 100 mg /kg. Bronchoconstriction was measured 24 h after the final drug administration. IPD-1151T inhibited both antigen- and MCh-mediated bronchoconstriction in actively sensitized mice. The inhibition induced was closely related to the dos e and frequency of oral administration of the agent. We also examined the effect of IPD-1151T on IgE production in response to DNP-KLH immunization. IPD-1151T inhibited dose-dependently both total and specific IgE concentrations in se rum prepared from mice 15 days after immunization. These results strongly indicate that IPD-1151T inhibits IgE production in vivo and results in attenuating effect on bronchoconstriction.
關鍵字
Anti-allergic agent ； Allergen ； Bronchoconstriction ； IgE ； IL-4 ； IPD-1151T ； Methacholine ； Mouse ； Suppression延伸閱讀
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