- 期刊
- OpenAccess
Combining mTOR Inhibitors with Chemotherapy and Other Targeted Therapies in Advanced Breast Cancer: Rationale, Clinical Experience, and Future Directions
並列摘要
Improvements in survival of patients with breast cancer have been attributed to the development of agents that target key components of dysregulated pathways involved in oncogenesis and progression of breast cancer. Aberrant mammalian target of rapamycin (mTOR) activation has been implicated in oncogenesis, angiogenesis, and the development of estrogen independence and resistance to chemotherapy in breast tumors. Several mTOR inhibitors (sirolimus, everolimus, temsirolimus, and ridaforolimus) have demonstrated antitumor activity in breast cancer cells. Combining mTOR inhibitors with endocrine therapies has demonstrated clinical antitumor activity in patients with metastatic breast cancer. In addition, mTOR inhibitor combinations with various targeted biologic agents or cytotoxic chemotherapeutic agents are being examined in more than 40 clinical trials with some early promising results. Combination therapies targeting multiple components of these central signaling pathways may be an optimal treatment strategy for patients with advanced breast cancer.
延伸閱讀
- Murphy, A., & Kelly, R. J. (2015). From Molecular Classification to Targeted Therapeutics: The Changing Face of Systemic Therapy in Metastatic Gastroesophageal Cancer. Gastroenterology Research and Practice, 2015(), 703-713-196. https://doi.org/10.1155/2015/896560
- Kripp, M., Horisberger, K., Mai, S., Kienle, P., Gaiser, T., Post, S., Wenz, F., Merx, K., & Hofheinz, R. D. (2015). Does the Addition of Cetuximab to Radiochemotherapy Improve Outcome of Patients with Locally Advanced Rectal Cancer? Long-Term Results from Phase II Trials. Gastroenterology Research and Practice, 2015(), 336-343-036. https://doi.org/10.1155/2015/273489
- 李耀泰、陳福民、沈仁達、郭宗正（2016）。The role of mTOR inhibitors for endometrial cancer。婦癌醫學期刊，(43)，9-13。https://www.airitilibrary.com/Article/Detail?DocID=P20150521002-201604-201605050012-201605050012-9-13
- Chen, P. S. (2009). Roles of Connective Tissue Growth Factor in Breast Cancer Metastasis and Drug Resistance [doctoral dissertation, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2009.10424
- 王董華（2019）。Long-term Outcomes and Predictors for response of Breast Cancer following Neoadjuvant Chemotherapy〔碩士論文，義守大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0074-2907201900252500