- 期刊
- OpenAccess
Liraglutide in Combination with Metformin or Sulfonylurea for the Treatment of Type 2 Diabetes in Adult Patients
並列摘要
Type 2 diabetes is a progressive disease characterized by decline in ����-cell function and insulin resistance. The development of liraglutide, a glucagon-like peptide 1 (GLP-1) receptor agonist, has been shown in clinical trials to be an effective drug with beneficial effects on β-cell function and improved glycemic control, without the side effects of weight gain and hypoglycemia that frequently limit the use of oral anti-diabetic drugs. Furthermore, its prolonged half-life makes it suitable for once daily administration. Liraglutide is demonstrated to be an effective agent in combination with commonly used oral antidiabetic drugs such as metformin and sulphonylureas, with a significant number of patients achieving their glycemic targets without hypoglycemia. In this review, the results from clinical trials utilizing liraglutide in combination with metformin or sulphonylurea are summarized with regards to efficacy and safety.
延伸閱讀
- Haak, T. (2015). Combination of Linagliptin and Metformin for the Treatment of Patients with Type 2 Diabetes. Clinical Medicine Insights: Endocrinology and Diabetes, (2015), 1-6. https://doi.org/10.4137/CMED.S10360
- Wang, B. M., Ma, W. Y., & Su, C. C. (2020). Effect of Liraglutide on Patients with Type 2 Diabetes in Real Practice: Experience from A Regional Hospital. 內科學誌, 31(3), 202-209. https://doi.org/10.6314/JIMT.202006_31(3).08
- Tseng, S. T., Yang, Y. S., & Huang, C. N. (2015). Fixed-Dose Combination Therapy of Rosiglitazone and Metformin for Drug-Naïve Type 2 Diabetes Mellitus. Formosan Journal of Endocrinology and Metabolism, 6(2), 70-80. https://doi.org/10.6856/FJEM.201512_6(2).0003
- Liu, S. C. (2012). Efficacy and safety of adding pioglitazone or sitagliptin to patients with type 2 diabetes insufficiently controlled with metformin and a sulfonylurea [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2012.02541
- Yabe, D., & Seino, Y. (2011). Liraglutide in Adults with Type 2 Diabetes: Global Perspective on Safety, Efficacy and Patient Preference. Clinical Medicine Insights: Endocrinology and Diabetes, (2011), 47-62. https://doi.org/10.4137/CMED.S5976