- 期刊
- OpenAccess
HLA Genetic Polymorphisms: Role in HIV-1 Susceptibility, Disease Progression and Treatment Outcomes
並列摘要
The human leukocyte antigen (HLA) gene loci are key in human immunodeficiency virus (HIV) antigen presentation leading to an immune response to infection. The high genetic variation in these gene loci forms the basis of the host's ability to mount immune responses to different viral epitopes. Polymorphisms of the HLA will impact susceptibility to HIV infection, disease progression, and treatment. This review aims at giving an overview on the role of HLA gene polymorphisms on HIV acquisition, rate of disease progression, and treatment outcomes. Understanding the HIV epitope-HLA complexes during infection might provide insight into the design of multi-epitope HIV vaccine for different populations.
延伸閱讀
- Mboowa, G. (2014). Genetics of Sub-Saharan African Human Population: Implications for HIV/AIDS, Tuberculosis, and Malaria. International Journal of Evolutionary Biology, (2014), 3-10. https://doi.org/10.1155/2014/108291
- Neto, O. D. S. P., Sá, K. S. G. D., Santana, B. B., Gomes, S. T. M., Amoras, E. D. S. G., Conde, S. R. D. S., Demachki, S., Azevedo, V. N., Feitosa, R. N. M., Ishak, M. D. O. G., Ishak, R., & Vallinoto, A. C. R. (2015). Lack of Association between Polymorphisms of the TLR4 Gene and Infection with the Hepatitis B and C Viruses. Mediators of Inflammation, 2015(), 393-399-034. https://doi.org/10.1155/2015/150673
- Lam, H. Y. (2010). The prevalence and genomic characterization of HIV-1 unique recombinant forms in Hong Kong [master's thesis, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200018637
- Yen, J. H., Tsai, W. C., Tsai, J. J., Chen, C. J., LIn, C. H., Ou, T. T., Wu, C. C., & LIu, H. W. (1999). HLA-DMA and HLA-DMB Genotyping in Patients with Rheumatic Diseases. The Kaohsiung Journal of Medical Sciences, 15(5), 263-267. https://doi.org/10.6452/KJMS.199905.0263
- Ulrickson, M., Press, O. W., & Casper, C. (2012). Epidemiology, Diagnosis, and Treatment of HIV-Associated Non-Hodgkin Lymphoma in Resource-Limited Settings. Advances in Hematology, 2012(), 676-682. https://doi.org/10.1155/2012/932658