- 期刊
- OpenAccess
Can Immunohistochemistry Serve as an Alternative to Subjective Histopathological Diagnosis of Oral Epithelial Dysplasia?
並列摘要
Many attempts have been made to identify objective molecular biomarkers to diagnose and prognosticate oral epithelial dysplasia (OED) because histopathological interpretation is subjective and lacks sensitivity. The majority of these efforts describe changes in gene expression at protein level in OED as determined by immunohistochemistry (IHC). However, the literature on these putative markers of oral cancer progression is vast and varied. The main purpose of this article is to review current knowledge on biomarkers of protein expression for OED by IHC approaches. We further discuss these findings in terms of the proposed essential hallmarks of cancer cells to better understand their role in oral oncogenesis.
延伸閱讀
- Koletsas, N., Koletsa, T., Choidas, S., Anagnostopoulos, K., Touloupidis, S., Zaramboukas, T., Raptou, G., Papadopoulos, N., & Lambropoulou, M. (2017). Immunohistochemical Investigation of HER/AKT/mTOR Pathway and Cellular Adhesion Molecules in Urothelial Carcinomas. Pathology Research International, 2017(), 1-7-005. https://doi.org/10.1155/2017/6794150
- Lam, S. C. (2004). A HRCT and immunohistochemistry study on bronchiectasis [master's thesis, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200004824
- 葉怡君（2007）。Immunohistochemical Analysis of Heat Shock Protein 27 & 60 in Periodontally Diseased Tissues〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://doi.org/10.6832/KMU.2007.00033
- Karimi, S., Shamaei, M., Pourabdollah, M., Sadr, M., Karbasi, M., Kiani, A., & Bahadori, M. (2014). Histopathological Findings in Immunohistological Staining of the Granulomatous Tissue Reaction Associated with Tuberculosis. Tuberculosis Research and Treatment, (2014), 187-192. https://doi.org/10.1155/2014/858396
- 梁錦榮、陳家榮（1998）。A Clinical & Immunohistochemical Study on over-expression of p53 Protein in Various Oral Mucosal Lesions。中華民國口腔顎面外科學會雜誌，9(1)，1-7。https://doi.org/10.7104/CJOMS.199803.0001