- 期刊
- OpenAccess
Wound Healing and Cancer Stem Cells: Inflammation as a Driver of Treatment Resistance in Breast Cancer
並列摘要
The relationship between wound healing and cancer has long been recognized. The mechanisms that regulate wound healing have been shown to promote transformation and growth of malignant cells. In addition, chronic inflammation has been associated with malignant transformation in many tissues. Recently, pathways involved in inflammation and wound healing have been reported to enhance cancer stem cell (CSC) populations. These cells, which are highly resistant to current treatments, are capable of repopulating the tumor after treatment, causing local and systemic recurrences. In this review, we highlight proinflammatory cytokines and developmental pathways involved in tissue repair, whose deregulation in the tumor microenvironment may promote growth and survival of CSCs. We propose that the addition of anti-inflammatory agents to current treatment regimens may slow the growth of CSCs and improve therapeutic outcomes.
延伸閱讀
- 蔡樂霖（2011）。The Study of Resistance to Chemotherapy in Cancer Stem Cells of Human Oral Squamous Cell Carcinoma〔博士論文，中山醫學大學〕。華藝線上圖書館。https://doi.org/10.6834/CSMU.2011.00067
- Schweizer, R., Tsuji, W., Gorantla, V. S., G.Marra, K., Rubin, J. P., & Plock, J. A. (2015). The Role of Adipose-Derived Stem Cells in Breast Cancer Progression and Metastasis. Stem Cells International, 2015(), 45-61-004. https://doi.org/10.1155/2015/120949
- Alemar, J., & Schuur, E. R. (2013). Progress in Using Circulating Tumor Cell Information to Improve Metastatic Breast Cancer Therapy. Journal of Oncology, 2013(), 177-184. https://doi.org/10.1155/2013/702732
- Casarsa, C., Oriana, S., & Coradini, D. (2008). The Controversial Clinicobiological Role of Breast Cancer Stem Cells. Journal of Oncology, 2008(), 13-24. https://doi.org/10.1155/2008/492643
- 陳喬依（2012）。Specific Targeting of MCF-7 Breast Cancer Stem Cells〔碩士論文，高雄醫學大學〕。華藝線上圖書館。https://www.airitilibrary.com/Article/Detail?DocID=U0011-3107201214072400