- 期刊
- OpenAccess
Atrial Natriuretic Peptide Single Nucleotide Polymorphisms in Patients with Nonfamilial Structural Atrial Fibrillation
並列摘要
Background: Atrial natriuretic peptide (ANP) has antihypertrophic and antifibrotic properties that are relevant to AF substrates. The -G664C and rs5065 ANP single nucleotide polymorphisms (SNP) have been described in association with clinical phenotypes, including hypertension and left ventricular hypertrophy. A recent study assessed the association of early AF and rs5065 SNPs in low-risk subjects. In a Caucasian population with moderate-to-high cardiovascular risk profile and structural AF, we conducted a case-control study to assess whether the ANP -G664C and rs5065 SNP associate with nonfamilial structural AF. Methods: 168 patients with nonfamilial structural AF and 168 age- and sex-matched controls were recruited. The rs5065 and -G664C ANP SNPs were genotyped. Results: The study population had a moderate-to-high cardiovascular risk profile with 86% having hypertension, 23% diabetes, 26% previous myocardial infarction, and 23% left ventricular systolic dysfunction. Patients with AF had greater left atrial diameter (44 ± 7 vs. 39 ± 5 mm; P＜ 0.001) and higher plasma NTproANP levels (6240 ± 5317 vs. 3649 ± 2946 pmol/mL; P＜ 0.01). Odds ratios (ORs) for rs5065 and -G664C gene variants were 1.1 (95% confidence interval [CI], 0.7-1.8; P = 0.71) and 1.2 (95% CI, 0.3-3.2; P = 0.79), respectively, indicating no association with AF. There were no differences in baseline clinical characteristics among carriers and noncarriers of the -664C and rs5065 minor allele variants. Conclusions: We report lack of association between the rs5065 and -G664C ANP gene SNPs and AF in a Caucasian population of patients with structural AF. Further studies will clarify whether these or other ANP gene variants affect the risk of different subphenotypes of AF driven by distinct pathophysiological mechanisms.
延伸閱讀
- Avci, I. I., Sahin, I., Gungor, B., Kücük, S. H., Sigirci, S., Varol, S., Tugrul, S., Atici, A., İnce, O., & Okuyan, E. (2021). Higher Copeptin Levels are Associated with the Risk of Atrial Fibrillation in Patients with Rheumatic Mitral Stenosis. Acta Cardiologica Sinica, 37(4), 412-419. https://doi.org/10.6515/ACS.202107_37(4).20210111A
- 廖重棋、鄭鴻璋、張佑好、田啟成、廖雅玲、張翠霞（2014）。An Assessment of the Heart Failure Diagnostic Capability of B-type Natriuretic Peptides Diuresis。澄清醫護管理雜誌，10(1)，15-19。https://www.airitilibrary.com/Article/Detail?DocID=18136702-201401-201402100038-201402100038-15-19
- 徐仲豪（2013）。The role of B-type natriuretic peptide in critical care of pediatric patients with congenital heart diseases〔博士論文，高雄醫學大學〕。華藝線上圖書館。https://doi.org/10.6832/KMU.2013.00033
- 賴家欣（2016）。Cardiopulmonary Function and Physical Activity in Patients with Atrial or Ventricular Septal Defects〔博士論文，國立臺灣師範大學〕。華藝線上圖書館。https://doi.org/10.6345/NTNU202204968
- Chen, Y. F., Li, H. B., Elton, T. S., Yang, R. H., Jin, H. K., & Oparil, S. Z. (1994). The Role of Atrial Natriuretic Peptide and Endothelin in Hypoxia Induced Pulmonary Hypertension. The Chinese Journal of Physiology, 37(3), 165-183. https://www.airitilibrary.com/Article/Detail?DocID=03044920-199409-37-3-165-183-a