- 期刊
- OpenAccess
Altered Calcium Handling and Ventricular Arrhythmias in Acute Ischemia
摘要
Acute ischemia results in deadly cardiac arrhythmias that are a major contributor to sudden cardiac death (SCD). The electrophysiological changes involved have been extensively studied, yet the mechanisms of ventricular arrhythmias during acute ischemia remain unclear. What is known is that during acute ischemia both focal (ectopic excitation) and nonfocal (reentry) arrhythmias occur, due to an interaction of altered electrical, mechanical, and biochemical properties of the myocardium. There is particular interest in the role that alterations in intracellular calcium handling, which cause changes in intracellular calcium concentration and to the calcium transient, play in ischemia-induced arrhythmias. In this review, we briefly summarize the known contributors to ventricular arrhythmias during acute ischemia, followed by an in-depth examination of the potential contribution of altered intracellular calcium handling, which may include novel targets for antiarrhythmic therapy.
延伸閱讀
- Sheu, S. H., Lin, C. C., & Chang, J. S. (1988). Arrhythmias in Patients with Mitral Valve Prolapse. The Kaohsiung Journal of Medical Sciences, 4(2), 81-90. https://doi.org/10.6452/KJMS.198802.0081
- Liu, Y. (2011). Novel insight into the mechanisms and treatment of ventricular tachyarrhythmias [doctoral dissertation, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200019636
- Xu, Y., Lin, H., Zhou, Y., Cheng, G., & Xu, G. (2013). Ceruloplasmin and the Extent of Heart Failure in Ischemic and Nonischemic Cardiomyopathy Patients. Mediators of Inflammation, 2013(), 1123-1129-100. https://doi.org/10.1155/2013/348145
- 陳劍平, 許陽峰, & 廖浩欽 (2014). Successful Treatment of Aconitine Induced Ventricular Tachyarrhythmia with Amiodarone: A Case Report. 台灣急診專科醫師期刊, 6(2), 65-67. https://www.airitilibrary.com/Article/Detail?DocID=2077351X-201412-201711240003-201711240003-65-67
- Dadkhah, S., Dowlatshahi, S., Sharain, K., & Sharain, R. (2011). Exercise Induced Non-Sustained Ventricular Tachycardia and Indication for Invasive Management. Clinical Medicine Insights: Cardiology, 2011(), 121-126. https://doi.org/10.4137/CMC.S8504