- 期刊
- OpenAccess
Basal Plasma Levels of Copeptin are Elevated in Inactive Inflammatory Bowel Disease after Bowel Resection
並列摘要
Evidence of interactions between the enteric nervous system, neuropeptides, and the immune system is growing. The aim of this study was to examine basal plasma levels of a variety of peptide precursors in patients with inflammatory bowel disease (IBD). In two middle-aged cohorts, Malmo Preventive Medicine (n = 5,415) and Malmo Diet and Cost Study (n = 6,103), individuals with the diagnosis of IBD were identified. Medical records were scrutinized. Three controls were matched for each patient. Copeptin, midregional fragments of adrenomedullin, pro-atrial natriuretic peptide, and proenkephalin A, as well as N-terminal protachykinin A and proneurotensin were analyzed in the plasma. Sixty-two IBD patients were identified. The only difference between patients and controls was higher copeptin levels in the patients compared with controls (P=0.006), with higher copeptin levels in resected than unresected patients (P=0.020). There was no difference in any precursor levels between Crohn’s disease and ulcerative colitis, between different distributions of disease lesions, or between different treatments.
延伸閱讀
- Michielan, A., & D’Incà, R. (2015). Intestinal Permeability in Inflammatory Bowel Disease: Pathogenesis, Clinical Evaluation, and Therapy of Leaky Gut. Mediators of Inflammation, 2015(), 291-300-329. https://doi.org/10.1155/2015/628157
- Opheim, R., Fagermoen, M. S., Jørgensen, L. P. J., Bernklev, T., & Moum, B. (2014). Sense of Coherence in Patients with Inflammatory Bowel Disease. Gastroenterology Research and Practice, 2014(), 1035-1043-142. https://doi.org/10.1155/2014/989038
- Jorgensen, L. P. J., Moum, B., & Bernklev, T. (2011). Worries and Concerns among Inflammatory Bowel Disease Patients Followed Prospectively over One Year. Gastroenterology Research and Practice, 2011(), 207-214. https://doi.org/10.1155/2011/492034
- Sorensen, H. B. (2012). Detection of Postoperative Intestinal Ischemia in Small Bowel Transplants. Journal of Transplantation, 2012(), 482-487. https://doi.org/10.1155/2012/970630
- Shieh, T. Y., Chen, M. J., Chang, C. W., Hung, C. Y., Hu, K. C., Kuo, Y. C., Shih, S. C., & Wang, H. Y. (2013). Effect of Physician-Delivered Patient Education on the Quality of Bowel Preparation for Screening Colonoscopy. Gastroenterology Research and Practice, 2013(), 643-647-093. https://doi.org/10.1155/2013/570180