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DNA Methylation of Regulatory Regions of Imprinted Genes at Birth and Its Relation to Infant Temperament
摘要
BACKGROUND: DNA methylation of the differentially methylated regions (DMRs) of imprinted genes is relevant to neurodevelopment. METHODS: DNA methylation status of the DMRs of nine imprinted genes in umbilical cord blood leukocytes was analyzed in relation to infant behaviors and temperament (n = 158). RESULTS: MEG3 DMR levels were positively associated with internalizing (β = 0.15, P = 0.044) and surgency (β = 0.19, P = 0.018) behaviors, after adjusting for birth weight, gender, gestational age at birth, maternal age at delivery, race/ethnicity, education level, smoking status, parity, and a history of anxiety or depression. Higher methylation levels at the intergenic MEG3-IG methylation regions were associated with surgency (β = 0.28, P = 0.0003) and PEG3 was positively related to externalizing (β = 0.20, P = 0.01) and negative affectivity (β = 0.18, P = 0.02). CONCLUSION: While the small sample size limits inference, these pilot data support gene-specific associations between epigenetic differences in regulatory regions of imprinted domains at birth and later infant temperament.
延伸閱讀
- Villela, D., Ramalho, R. F., Silva, A. R. T., Brentani, H., Suemoto, C. K., Pasqualucci, C. A., Grinberg, L. T., Krepischi, A. C. V., & Rosenberg, C. (2016). Differential DNA Methylation of MicroRNA Genes in Temporal Cortex from Alzheimer's Disease Individuals. Neural Plasticity, 2016(), 698-707-057. https://doi.org/10.1155/2016/2584940
- Guénard, F., Tchernof, A., Deshaies, Y., Cianflone, K., Kral, J. G., Marceau, P., & Vohl, M. C. (2013). Methylation and Expression of Immune and Inflammatory Genes in the Offspring of Bariatric Bypass Surgery Patients. Journal of Obesity, 2013(), 559-567. https://doi.org/10.1155/2013/492170
- Meysman, P., Marchal, K., & Engelen, K. (2012). DNA Structural Properties in the Classification of Genomic Transcription Regulation Elements. Bioinformatics and Biology Insights, 2012(), 155-168. https://doi.org/10.4137/BBI.S9426
- 林依樺（2015）。Influence of Prenatal Exposure to Phthalates and Phenols on DNA Methylation in Inflammatory Genes〔碩士論文，國立臺灣大學〕。華藝線上圖書館。https://doi.org/10.6342/NTU.2015.01168
- Chen, C. (2001). A study of genomic imprinting and DNA methylation in gynecological cancers [doctoral dissertation, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200007828