Reactive Oxygen Species: Physiological and Physiopathological Effects on Synaptic Plasticity

Thiago Fernando Beckhauser ； José Francis-Oliveira ； Roberto De Pasquale

《Journal of Experimental Neuroscience》 2016-S1期 (2016/12) Pp. 23-48

https://doi.org/10.4137/JEN.S39887

摘要

In the mammalian central nervous system, reactive oxygen species (ROS) generation is counterbalanced by antioxidant defenses. When large amounts of ROS accumulate, antioxidant mechanisms become overwhelmed and oxidative cellular stress may occur. Therefore, ROS are typically characterized as toxic molecules, oxidizing membrane lipids, changing the conformation of proteins, damaging nucleic acids, and causing deficits in synaptic plasticity. High ROS concentrations are associated with a decline in cognitive functions, as observed in some neurodegenerative disorders and age-dependent decay of neuroplasticity. Nevertheless, controlled ROS production provides the optimal redox state for the activation of transductional pathways involved in synaptic changes. Since ROS may regulate neuronal activity and elicit negative effects at the same time, the distinction between beneficial and deleterious consequences is unclear. In this regard, this review assesses current research and describes the main sources of ROS in neurons, specifying their involvement in synaptic plasticity and distinguishing between physiological and pathological processes implicated.

關鍵字

reactive oxygen species ； synaptic plasticity ； oxidative stress