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Phenotypic and Genotypic Characteristics of Small Colony Variants and Their Role in Chronic Infection
並列摘要
Small colony variant (SCV) bacteria arise spontaneously within apparently homogeneous microbial populations, largely in response to environmental stresses, such as antimicrobial treatment. They display unique phenotypic characteristics conferred in part by heritable genetic changes. Characteristically slow growing, SCVs comprise a minor proportion of the population from which they arise but persist by virtue of their inherent resilience and host adaptability. Consequently, SCVs are problematic in chronic infection, where antimicrobial treatment is administered during the acute phase of infection but fails to eradicate SCVs, which remain within the host causing recurrent or chronic infection. This review discusses some of the phenotypic and genotypic changes that enable SCVs to successfully proliferate within the host environment as potential pathogens and strategies that could ameliorate the resolution of infection where SCVs are present.
延伸閱讀
- Elvidge, C. K., & Brown, G. E. (2015). Nonconsumptive Effects of Predation and Impaired Chemosensory Risk Assessment on an Aquatic Prey Species. International Journal of Ecology, 2015(), 119-127. https://doi.org/10.1155/2015/894579
- Gaetano, C. D., Matullo, G., Piazza, A., Ursino, M., & Gasparini, M. (2013). A Proximity-Based Method to Identify Genomic Regions Correlated with a Continuously Varying Environmental Variable. Evolutionary Bioinformatics, (2013), 29-42. https://doi.org/10.4137/EBO.S10211
- Tang, G. (2004). Molecular and phenotypic characteristics of the genus actinomyces withparticular reference to the human oral cavity [doctoral dissertation, The University of Hong Kong]. Airiti Library. https://www.airitilibrary.com/Article/Detail?DocID=U0029-1812201200003908
- Peng, P. C. (2013). Gene Regulatory Network Inference and Complex Phenotype Prediction from Genetical Genomics Data [master's thesis, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2013.02633
- Flatscher, R., Frajman, B., Schonswetter, P., & Paun, O. (2012). Environmental Heterogeneity and Phenotypic Divergence: Can Heritable Epigenetic Variation Aid Speciation?. Genetics Research International, 2012(), 229-237. https://doi.org/10.1155/2012/698421