Effect of Curcumin on Statin Induced Short Term Memory Loss

Jithendra Chimakurthy ； Talasila EGK Murthy

《Journal of pioneering medical sciences》 2卷2期 (2012/06) Pp. 53-57

並列摘要

BACKGROUND: The present investigation was undertaken to explore the effect of curcumin on rosuvastatin-induced short-term memory loss. MATERIALS AND METHODS: For our study, we built an experimental model that consisted of a box with a starting point at one end and an ending point at the other end. These two points were separated by three partitions which had interconnecting doors. Control and rosuvastatin-treated rats received different treatments orally; control (vehicle), negative control, 5mg/kg and 10 mg/kg of curcumin and 150mg/kg of piracetam (standard) for 14 days. Rosuvastatin 10mg/kg p.o. was administered to all the four groups except control. At the end of the treatment, rats were placed individually in the apparatus and allowed to explore the pattern of doors. After initial exposure the rats were placed individually and the latency to cross each door was recorded, the reduction in the time taken to cross the 3rd door when compared to the time taken to cross the 1st door is taken as an index of short term memory protection. RESULTS: Rosuvastatin-treated group (negative control) did not show any decrease in the time taken to cross the 3rd door when compared to the time taken to cross the 1st door. Treatment with curcumin at both 5 and 10mg/kg showed a significant decrease (p＜0.001) in the time taken to cross the 3rd door when compared to the time taken to cross the 1st door and were comparable with that of piracetam-treated group. CONCLUSION: Our study shows evidence for the protective effect of curcumin against rovustatin induced short-term memory loss. We suggest further studies be done in order to explore the relationship in humans.

並列關鍵字

Short term memory ； Curcumin ； Antioxidant ； Rosuvastatin