建立彩色數位血管攝影分析平台-使用於腦部血流動力學參數測量

Establishing Color-coded DSA Platform in Measurement of Cerebral Hemodynamic Parameters

江蓮(Lien Chiang) ； 高怡宣(Yi-Hsuan Kao) ； 林重榮(Chung-Jung Lin) ； 鄧木火(Michael Mu-Huo Teng) ； 黃姍姒(Shan-Su Huang) ； 張建法(Chien-Fa Chang)

《北市醫放雜誌》 5卷1期 (2015/12) Pp. 13-20

https://doi.org/10.6663/TPART.2015.5.1.13

摘要

臨床上數位血管攝影技術無論在診斷或是治療腦部疾病時，僅能得到結構性解剖資訊作為相關的診斷，而無法得到相關功能性的資訊。因此本研究的研究目的為發展一套跨廠牌的分析平台，使用彩色數位血管攝影(color-coded digital subtraction angiography, color-coded DSA)技術，將數位血管攝影影像作量化的分析，作為進一步進行腦血管疾病的研究。本研究中，使用程式語言編寫程式，將原始數位血管攝影之影像的每一個像素中，對比劑到達最大濃度所花的時間(Time to Peak, TTP)計算出，再搭配適當的色階與編碼，便可以繪製出Color-coded DSA 影像。再將影像中的時間對比劑濃度曲線，使用伽傌變數函數(gamma variates function)做曲線擬合，得到該曲線的特性參數，以做為血流動力學參數。實驗結果以放置支架為治療方式的頸動脈狹窄患者為例，在color-coded DSA影像中可以明顯看到，在放置支架治療後，Color-coded DSA 影像呈現疏通的血管變多，影像也變得較為明亮並偏暖色系，可以看見血流動力學參數也有明顯改變。從color-coded DSA 影像中，除了得到高解析度的血管影像之外，更可以藉由圈選特定血管ROI的方式，得到該血管的血流動力學資訊，做功能性的評估。Color-coded DSA 可以即時監測病患的腦部循環狀況，讓數位血管攝影在解剖結構資訊之外，多了功能性的資訊，不但不花費額外的對比劑與輻射劑量，相信也即將是未來的研究方向。

關鍵字

彩色數位血管攝影 ； 數位血管攝影

並列摘要

Digital subtraction angiography can provide anatomical information but less functional information for clinical doctor during diagnosis and treatment of cerebrovascular diseases. Therefore the purpose of this study is to develop a cross-brand platform to quantify the cerebral hemodynamic parameters in DSA images by color-coded DSA technique to study cerebrovascular diseases fatherly. In this study, color-coded quantitative DSA is generated by the maximum intensity of series dynamic DSA images, which is Time To Peak (TTP), and a color code. The time-concentration curve of the color-coded DSA image was fitted to a gamma-variate function. Then the characteristic parameters are calculated from the time-concentration curve as hemodynamic parameters. In the result, we take a case who suffered from carotid stenosis and received stent placement treatment for example. In the color-coded DSA images, it shows that the color of the image became brighter and the hemodynamic parameters improved significantly. Color-coded DSA can provide not only high resolution image but functional hemodynamic information by selecting region of interest (ROI). We can monitor the brain circulation of patient in real time by color-coded DSA. It can provide anatomical and functional information. Moreover, it doesn't need any more contrast medium and radiation dose.

並列關鍵字

Color-coded Digital Subtraction Angiography (Color-coded DSA) ； Digital Subtraction Angiography (DSA)