脊髓損傷患者在大腦中磁振頻譜的變化

在台灣地區，每年新增約有2500 名脊髓損傷病例，外傷性原因以車禍居多，佔了百分之五十以上，脊髓損傷(Spinal cord injury，簡稱SCI)，是指急性外傷傷害了脊髓與神經，造成運動、感覺及大小便功能失常。頸髓受傷會造成四肢癱瘓，約佔所有脊髓損傷患者的半數；若傷及胸髓、腰髓或薦髓，則會造成下半身癱瘓。除了運動與感覺機能障礙外，脊髓損傷還會造成排尿、排便困難及性功能障礙，及呼吸問題、自主神經機能異常且常伴隨著慢性疼痛。磁振造影(Magnetic Resonance Imaging，簡稱MRI)在脊髓損傷臨床診斷中應用越來越廣泛，MRI的脊椎造影能從橫縱兩個方向同時清楚顯示脊椎及脊髓的改變，本研究更針對可配合的患者做腦部的掃瞄，利用磁振頻譜(Magnetic resonance spectroscopy, MRS)的檢查搭配LC Model 的軟體來做定量分析，得到腦部的代謝物變化。結果顯示腦中的肌酸(Creatine, Cr)和磷酸肌酸(Phosphocreatine, PCr)有顯著下降，而肌酸和磷酸肌酸則和肌肉、神經細胞間的能量傳遞息息相關。

關鍵字

脊髓損傷；核磁共振頻譜；肌酸；磷酸肌酸

並列摘要

2,500 cases of spinal cord injury were increased each year in Taiwan, and the traumatic causes were mostly car accident, accounting for more than 50%. Spinal cord injury (SCI) was referred to acute traumatic injury, invasion of the spinal cord and nerves, resulting in motor, sensory and urine dysfunction. Cervical spinal cord injury can cause limb paralysis, and accounting for about half of all patients with spinal cord injury. If injured the spinal cord of thoracic, lumbar, or sacrum, it will cause lower body paralysis. In addition to exercise and sensory dysfunction, spinal cord injury can cause voiding, defecation difficulties and sexual dysfunction, and respiratory problems, autonomic dysfunction and often accompanied by chronic pain. Magnetic Resonance Imaging (MRI) is widely used in the clinical diagnosis of spinal cord injury. MRI can be used to show the changes of spine and spinal cord from both sagittal and axis directions. This study was collected SCI patients suitable for MRI brain scan, and used magnetic resonance spectroscopy (MRS) with LC Model software to do quantitative analysis the biological metabolism changes in brain. The results showed that creatine (Cr) and phosphocreatine (PCr) were significantly decreased. Creatine and phosphocreatine were closely related to the energy transfer between muscle and nerve cells.

並列關鍵字

Spinal cord injury ； Magnetic resonance spectroscopy ； Creatine ； Phosphocreatine

國際替代計量

脊髓損傷患者在大腦中磁振頻譜的變化

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