This paper aims to investigate how the alien prajna science, after its introduction to China from Middle Asia in early fifth century, interacted with the local nirvana thought and finally moulded the mainstream of Chinese Buddhology thought. In late Jin Dynasty, the sangha order of kumarajiva in Northern China promoted "prajna emptiness" while the sangha order of Huiyuan in Southern China expounded "nirvana existence." They developed their own doctrinal system, style of thought and meditation technique." The most critical dispute appeared between them in the history of Chinese Buddhism. After dispute, the two schools gradually integrated. The appearing of "doctrinal criticism" is the starting of integration. And, the appearing of different schools in Sui and Tang Dynasties symbolizes the completion of this integration.