摘要
瀰漫性泛細支氣管炎(diffuse panbroncheolitis) 是一病因待研究的小細支氣管發炎性疾病。該病好發亞洲人種，會造成漸進性的阻塞性通氣障礙終至支氣管擴張與呼吸衰竭。病患除常合併鼻竇炎外，影像學可見典型的樹芽狀(tree in bud) 型態。近年發現長期使用Macrolide 類抗生素，可藉其免疫調節(immunomodulation) 的機制來有效改善患者預後。
參考文獻
Steel HC, Theron AJ, Cockeran R, et al. Pathogen- and host-directed anti-inflammatory activities of macrolide antibiotics. Mediators Inflamm 2012; 2012:584262."
Homma H, Yamanaka A, Tanimoto S, et al. Diffuse panbronchiolitis: a disease of the transitional zone of the lung. Chest 1983;83:63-9."
Sugiyama Y, Kudoh S, Maeda H, et al. Analysis of HLA antigens in patients with diffuse panbronchiolitis. Am Rev Respir Dis 1990;141:1459-62."
Park MH, Kim YW, Yoon HI, et al. Association of HLA class I antigens with diffuse panbronchiolitis in Korean patients. Am J Respir Crit Care Med 1999; 159:526-9."
Baz MA, Kussin PS, Van Trigt P, et al. Recurrence of diffuse panbronchiolitis after lung transplantation. Am J Respir Crit Care Med 1995; 151:895."