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晚期肝癌以nivolumab接續肝臟移植的成功案例

摘要


近年來,免疫治療在許多種癌症展現突破性的療效,也成為多種癌症的標準療程之一,其中programmed cell death protein-1(PD-1)抑制劑已是肝癌的二線標準治療藥物。然而,使用PD-1抑制劑後進行器官移植的安全性是目前未知的。本文提出一位晚期肝癌用nivolumab使腫瘤達到完全緩解,但因免疫相關膽管炎而停用nivolumab,並於一年後能成功接受肝臟移植的案例。此案例顯示,在適當時間間隔下,PD-1抑制劑在器官移植前使用是安全的。

參考文獻


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