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以實證醫學的角度探討部份水解配方在功能性腸胃疾病的角色

摘要


功能性腸胃疾病(functional gastrointestinal disorders)為一群慢性、反覆發作、無法以解剖學的病變或生化學的異常來解釋的腸胃道疾病,其表現相當廣泛,根據年齡有不同的表現,而在嬰兒時期包括胃食道逆流(regurgitation)、嬰兒腸絞痛(infantile colic)、功能性便祕(functional constipation)等。雖然這些功能性腸胃疾病會隨著年齡逐漸改善,但腸胃道的不適,常讓嬰兒哭鬧不安、難以安撫,並影響照顧者的生活品質。目前對於功能性腸胃疾病的病生理機轉有許多假說,並不能以單一原因解釋。在對患有功能性腸胃疾病且不能哺餵母乳的嬰兒族群,將配方奶粉調整為部份水解配方(partially hydrolyzed formulas)是緩解相關腸胃症狀的臨床策略之一。本篇將以實證醫學的角度探討部份水解配方在功能性腸胃疾病的角色。

參考文獻


Zeevenhooven J, Koppen IJ, Benninga MA. The New Rome IV Criteria for Functional Gastrointestinal Disorders in Infants and Toddlers. Pediatr Gastroenterol Hepatol Nutr 2017;20:1-13.
Vandenplas Y, Cruchet S, Faure C, et al. When should we use partially hydrolysed formulae for frequent gastrointestinal symptoms and allergy prevention? Acta Paediatr 2014;103:689-95.
Vandenplas Y, Leluyer B, Cazaubiel M, et al. Double-blind comparative trial with two antiregurgitation formulae. J Pediatr Gastroenterol Nutr 2013;57:389-93.
Savino F, Cresi F, Maccario S, et al. “Minor” feeding problems during the first months of life: effect of a partially hydrolysed milk formula containing fructo- and galactooligosaccharides. Acta Paediatr Suppl 2003;441:86-90.
Vandenplas Y, Abkari A, Bellaiche M, et al. Prevalence and health outcomes of functional gastrointestinal symptoms in infants from birth to 12 months of age. J Pediatr Gastroenterol Nutr 2015;61:531-7.

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