The main difference between art museums and other kinds of museums is that art museums exhibit and collect original and valuable art works. Traditional art museum exhibitions are mostly designed to display art works in themed sections, and are not focused on the integration of space and works. Modern exhibitions, however, emphasize the concept of "simplicity" and try to combine art works and exhibition space. Thus, aesthetic knowledge is indispensable for curators today. Based on the concepts of exhibition design and spatial planning, this paper discusses the interactive relationship between exhibition space and the display of art works by referring to examples of exhibitions in Taiwanese and foreign art museums, academic studies, and the author's own practical experience. This paper offers suggestions for design of art work displays in five areas: 1) creating a dialogue with art works, 2) ensuring sufficient flow, 3) developing interaction between art works, 4) focusing on visual effects, and 5) expressing curatorial concepts.