- 期刊
- OpenAccess
Influence of Tumor Depth on the Outcome of Patients with pT3N0 Oral Cavity Squamous Cell Carcinoma According to the AJCC Cancer Staging Manual, 8th Edition
摘要
Background: The AJCC Cancer Staging Manual, 8th Edition (American Joint Committee on Cancer [AJCC]-8, 2017) introduces depth of invasion (DOI) as a factor in oral cavity squamous cell carcinoma (OSCC), with DOI ＞ 10.0 mm leading to an upstaged T3 classification. We aimed to compare the outcome of patients with AJCC-8 pT3N0 OSCC according to the AJCC Cancer Staging Manual, 7th Edition (AJCC-7, 2010) criteria. Methods: Treatment-naïve patients diagnosed with AJCC-8 pT3N0 OSCC (n = 277) between 1996 and 2015 were retrospectively reviewed. Four subgroups were created according to the AJCC-7 criteria: prior pT1N0/DOI ＞ 10.0 mm, prior pT2N0/DOI ＞ 10.0 mm, prior pT3N0/DOI ≤ 10.0 mm, and prior pT3N0/ DOI ＞ 10.0 mm. Five-year local control, neck control, distant metastasis (DM), disease-free survival (DFS), and disease-specific survival (DSS) rates were analyzed. Results: Prior pT1N0/DOI ＞ 10.0 mm was associated with local control, neck control, DFS, and DSS rates of 100.0%. Prior pT3N0/DOI ＞ 10.0 mm was associated with the highest rate of DM and was the only independent risk factor for 5-year DM. A subgroup analysis of prior pT3N0 patients revealed that DOI ＞ 10.0 mm was associated with higher 5-year DM and lower DFS and DSS rates and was the only independent risk factor for 5-year DM, DFS, and DSS. Conclusions: Prior pT1N0/DOI ＞ 10.0 mm was associated with the most favorable outcome and may not qualify as a new AJCC-8 pT3N0 category. Prior pT3N0/DOI ＞ 10.0 mm was associated with the poorest outcome. Therefore, these patients may benefit from radical surgery, postoperative adjuvant therapy, and close monitoring as an early detection strategy.
延伸閱讀
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