- 期刊
- OpenAccess
Intensity Modulated Proton Therapy for Head and Neck Cancer-Less Pain, Same Gain
摘要
Background: Radiotherapy plays an important role in treatment for head and neck cancer (HNC). However, radiotherapy also caused a lot of uncomfortable adverse events. The physical characteristics of the proton beam offer advantages of precision. With the invention of intensity modulated proton therapy (IMPT) technique, the theoretical advantages can be realized. Since IMPT are more accessible, physicians who participate in the treatment of HNC should know the updated information of IMPT. This article provides a quick review and current clinical experience of IMPT in treatment of HNC. Methods: A literature review. Results: Dosimetric studies of IMPT for treatment of various HNC showed that IMPT could significantly reduce the radiation dose distributed to surrounding normal tissues, comparing to the photon radiotherapy. Preliminary clinical results demonstrated the benefits in reducing treatment-related toxicities, with similar tumor control and survivals. However, there are still some limitations of IMPT and prospective trials are required to provide solid evidence about clinical benefit. Conclusions: Current evidence suggests that IMPT is feasible and safe for treating HNC. It is superior in terms of reducing toxicity while tumor control is similar. As the number of proton therapy centers increased over the world, large scale prospective clinical trials should be raised to improve the treatment results of HNC through application of IMPT.
延伸閱讀
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