- 期刊
- OpenAccess
Analysis of De Novo and Radiation-Induced Sarcomatoid Carcinoma of Head and Neck: A Single-Center Experience
摘要
Background: We demonstrate our institutional experience of treatment to de novo sarcomatoid carcinoma (SaC) and radiation-induced SaC (RISaC) of head and neck. The following groups were analyzed with relation to survival: (1) de novo SaC and RISaC, (2) surgery and non-surgery, and (3) conventional radiation therapy (RT) and hyperfractionated RT. Methods: From March 2015 to January 2020, 22 adult patients who received treatment for SaC of the head and neck in our institution were included. Fourteen were diagnosed with de novo SaC and 8 were diagnosed with RISaC. The cases were analyzed on the age, sex, tumor location, biopsy number, TNM (tumor, node, metastasis) stage, surgery, RT, chemotherapy, and survival time. Results: The median survival time of de novo SaC was 17 months and RISaC was 6 months (range, 2-36 months). There was a statistically significant difference between these two groups. However, there were also a difference in age between the groups (p = 0.039), which was a confounder. The surgery group had a tendency of longer survival time than the non-surgery group, but there was no statistically significant difference. Patients who received conventional RT seemed to have a better survival rate than patients who received hyperfractionated RT, but there was no statistically significant difference. Conclusions: The limitations of this study were the small sample size and selection bias on treatment choice.
延伸閱讀
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