Systemic Inflammation Response Index in Head and Neck Cancer: A Meta-Analysis of Prognostic Value

Yun-Ting Wang ； Liang-Tseng Kuo ； Geng-He Chang ； Yi-Chan Lee ； Cheng-Ming Hsu ； Ethan I. Huang ； Ming-Shao Tsai ； Yao-Te Tsai

《International Journal of Head and Neck Science》 6卷1期 (2022/03) Pp. 17-27

https://doi.org/10.6696/IJHNS.202203_6(1).0002

摘要

Background: The prognostic value of systemic inflammation response index (SIRI) has been reported in head and neck cancer (HNC), but the results are still controversial. We conducted this meta-analysis to investigate the prognosis value of SIRI in HNC. Methods: The systemic search of Cochrane Library databases, EMBASE, MEDLINE, and PubMed for eligible studies was conducted to assess the associations between SIRI and survival outcomes of HNC, including overall survival (OS), disease-specific survival (DSS), and progression-free survival (PFS). A total of 11 studies including 4,052 patients were enrolled in this meta-analysis. By using random-effects models, the hazard ratio (HR) was pooled with 95% confidence interval (CI). Results: The pooled results revealed that elevated SIRI before treatment was associated with worse OS (HR: 2.17; 95% CI: 1.68-2.82; p ＜ 0.001), DSS (HR: 2.29; 95% CI: 1.77-2.97; p ＜ 0.001), and PFS (HR: 2.25; 95% CI: 1.61-3.16; p ＜ 0.001) in HNC. The subgroup analysis revealed the consistent prognostic impact of SIRI on OS. Conclusion: The SIRI has potential to be a prognostic biomarker in patients with HNC.

關鍵字

systemic inflammation response index ； head and neck cancer ； meta-analysis ； prognostic biomarker ； survival outcomes