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Clinical Importance of Preoperative Geriatric Nutritional Risk Index in Head and Neck Cancer Patients With Free Flap Reconstruction
摘要
Background: This retrospective cohort study was to assess the predictive value of preoperative geriatric nutritional risk index (GNRI) on postoperative wound infection for patients with head and neck squamous cell carcinoma (HNSCC) who have undergone radical surgery with free flap reconstruction. Methods: A total of 255 patients with HNSCC undergoing tumor resection and immediate microvascular free flap reconstruction at a single institute from December 2008 to December 2011 were enrolled. The primary endpoint was the predictability of postoperative wound infection. Statistical analyses including Pearson's chi-squared test which was used to determine whether there was an association between each selected clinical factor and postoperative wound infection. Logistic regression analysis was performed to ascertain the effects of selected variables on the likelihood that patients have postoperative wound infection. Results: Preoperative GNRI, pT classification, pN classification, and tumor location were significantly associated with postoperative wound infection in univariate analysis. Logistic regression analysis showed an increased risk of postoperative wound infection among patients with preoperative high-risk group of GNRI compared to patients with preoperative no-risk group of GNRI (odds ratio: 4.883; 95% confidence interval: 1.607-14.836; p=0.005). Conclusion: Our results suggest that preoperative GNRI serves as a useful indicator for the development of postoperative complications for patients with HNSCC undergoing tumor resection and immediate microvascular free flap reconstruction.
延伸閱讀
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