The Influence of Focal Ischemic Brain Injury on Tail-Flick Latency in the Rat

局部腦缺血對老鼠Tail-Flick Latency的影響

蔡玉娟(Yu-Chuan Tsai) ； 黃顯哲(Shean-Jer Huang) ； 張傳林(Chuan-Lin Chang)

《Acta Anaesthesiologica Sinica》 32卷2期 (1994/06) Pp. 115-120

摘要

Tail-flick latency (TFL), a measure of response threshold to pain, was investigated in rats with focal ischemic brain injury resulting from middle cerebral artery occlusion (MCAO) as compared to sham and non-operative (non-op) groups on the 1st, 7th, 14th, 21th and 28th days following surgery or anesthesia. No significant differences were observed between MCAO and sham groups postoperatively, indicating focal ischemic insult induced by this model had no significant influence on TFL. Increased sensitivity to TFL in early postoperative period was shown when compared sham or MCAO with non-op group. The correlation between TFL and the time from surgery was statistically significant on the 1st and 7th days in sham group and the 1st, 7th and 14th days in MCAO group. We conclude that the focal ischemic injury resulting from middle cerebral artery occlusion that has no obvious neurologic effects does not alter pain threshold; however, surgical procedure increases postoperative sensitivity to pain stimulation.

關鍵字

Tail-flick latency ； Brain: infarction ； ischemia ； Animal: rat

並列摘要

觀察經中腦動脈結紮後引起局部腦缺血（MCAO組）的老鼠，其Tail-Flick Latency（TFL）（－測量痛閥反應的指標），並與僞裝組（Sham組）和没有接受手術組（Nov-op組）比較之。於手術或麻醉後第1，7，14，21和28天觀察TFL之變化。MCAO和Sham兩組間，TFL並無統計學上之差異。在手術後第1和第7天，可發現MCAO或Sham組之TFL與Non-op組比較爲低。此結果顯示，以此模式結紮中腦動脈引起老鼠局部腦缺血並不會影響TFL，即不會影響痛閥反應；而手術本身則會增加術後對痛刺激之敏感度。