Gastroesophageal reflux disease (GERD) is a disease with high prevalence in modern society. The most common symptoms includes heart burning and regurgitation. Chest pain, dysphagia, dry cough, hoarseness, and globus sensation are also noted in some cases. The treatment of GERD now are medication and patient education. In some severe cases, surgical intervention should be considered. Besides, emotional problem due to life stress should be concerned in these patients. Chinese medicine is focus on the balance between stomach, spleen, and kidney. In this case, a 43-year-old male, who had suffered from epigastric burning sensation, epigastric fullness, and regurgitation for more than 5 years, received panendoscope exam and was diagnosed as GERD. The symptoms subsided after medication treatment, but was recurrent again after medication was stopped. Therefore, he visited our Chinese Medicine department. After 1-month-course of treatment with Chinese Medicine, all the symptoms had been improved, and he didn't take western medicine anymore. In this case report, Chinese Medicine is proved to be a efficient treatment in GERD.