- 期刊
甲狀腺癌患者消融治療時的I-131體內動力學研究
To Evaluate the Biokinetic Model of Iodine-131 for Thyroidectomy Patients
摘要
體內動力學模型是一用來描述人體攝入特定放射性物質後，放射性物質在人體內的分佈路徑、強度、循環以及排泄的情形。國際放射防護委員會(International Commission on Radiological Protection, ICRP)在其出版的30號報告，提出了碘的體內動力學模型。然而，模型的數據來源是標準健康受試者，對於臨床上經甲狀腺全切除術的甲狀腺癌患者而言顯然並不適用。本研究針對四位甲狀腺已切除並即將接受I-131消融治療之患者進行I-131的體內動力學研究。研究結果顯示四位受試者的胃、體液和甲狀腺的平均碘生物半衰期分別為0.0177±0.0062天、0.4375±0.0417天、3.125±0.7217天；平均路徑強度I_(23)、I_(25)分別為 0.34±0.19、0.66±0.19。與ICRP模型所描述的0.029天、0.25天、80天、以及I_(23)、I_(25)為0.3、0.7相較之下，甲狀腺已切除的甲狀腺癌患者，I-131在其胃、體液+全身和甲狀腺的平均碘生物半衰期、平均路徑強度皆有顯著變化。
並列摘要
The biokinetic model is used to describe the distribution path, intensity, circulation, and excretion in the human body after intake specific radiopharmaceutical. The report No.30 of the International Commission on Radiological Protection (ICRP) provided recommendations for the biokinetic of iodine-131. However, the model suggested data are for standard healthy human and obviously not applicable to thyroid cancer patients undergone total thyroidectomy. Thus, this study investigated the biokinetic model of iodine-131 in four patients who had undergone thyroidectomy and given administration of iodine-131 for ablation. The average biological half-life of I-131 in stomach, body fluid and thyroid of the four subjects was 0.0177±0.0062, 0.4375±0.0417, and 3.125±0.7217 days, respectively derived from the direct gamma camera scanning; the average path strengths of body fluid to thyroid, I_(23) and to excretion, I_(25) was 0.34±0.19 and 0.66±0.19, respectively. In conclusion, the biological half-life of iodine in various compartments changed significantly in remaining thyroid of total thyroidectomy patients.