- 期刊
高血醣受檢者進行氟化去氧葡萄糖（F-18 FDG）腦部掃描之病例報告
Fluorodeoxyglucose (F-18 FDG) Brain Scans in Hyperglycemic Patient-Case Report
摘要
氟化去氧葡萄醣（F-18 FDG；FDG）廣泛用於腦部神經學（neurology）檢查，並且被認為是當前人腦研究最準確的體內方法。本科亦普遍應用在輕度認知障礙（mild cognitive impairment; MCI）早期診斷與各類型失智症診斷、運動障礙與神經退化性疾病診斷、腦腫瘤與精神疾病檢查。本案例報告即針對一名嗜睡症（narcolepsy）研究案受檢者在高血醣（hyperglycemia）情形下，以PETMR進行腦部FDG PET scan的案例做文獻探討FDG在高血醣狀態下的腦部代謝情形。發現受影響區域多發生在頂葉、扣帶迴、額葉等處，所謂的AD相關區域（AD related regions），但是仍無法清楚的明瞭其影響程度。依據參考文獻與我們自身經驗討論後，認為高血醣狀態對腦部FDG分佈有一定影響，但並未嚴重到無法判讀。臨床有需要時，本案例藉由量化分析工具診斷並與過去資料比對的方式可以做為臨床決策參考。
並列摘要
Fluorodeoxyglucose (F-18 FDG) is widely used in neurological examinations, and it considered to be the most accurate in vivo method currently available for human brain research. We also routine used in the early diagnosis of mild cognitive impairment (MCI) and the diagnosis of various types of dementia, movement disorders, neurodegenerative diseases and brain tumors and psychiatric diseases. In our case report we discuss about a narcolepsy patient with hyperglycemia, and who come for the brain FDG PET scan with PETMR. According the references, the FDG distribution changes in the brain is mostly occurred in the parietal lobe, basal ganglia, frontal lobe also called AD related regions, but the extent of its impact cannot be clearly known. Based on references and our own experience, we believe that the hyperglycemic state has a certain effect on the distribution of FDG in the brain, but it is mild and will not affect the reliability of the examination. When necessary, the quantitative tools and compared with history data that we use in this case, which can be used as a reference for clinical decision-making.
延伸閱讀
- Chang, P. L., Shen, D. H. Y., Yang, K. T., Hung, G. U., Huang, W. S., Cheng, C. Y., Yu, C. P., Lin, C. K., & Peng, Y. J. (2006). Rosai Dorfman病的氟－18-去氧葡萄糖之正子電腦斷層影像：個案報告. 核子醫學雜誌, 19(4), 265-269. https://doi.org/10.6332/ANMS.1904.007
- Chen, S. W., Yeh, C. L., Chen, Y. K., & Liao, C. S. (2008). 利用氟－18-去氧葡萄糖的代謝來區分原發性肝細胞癌及乳癌肝臟轉移之鑑別診斷：一病例報告. 核子醫學雜誌, 21(3), 177-181. https://doi.org/10.6332/ANMS.2103.006
- Lin, C. Y. (2011). 探討血清全氟碳化合物與肝功能、甲狀腺功能、血糖調控與心血管疾病危險因子之相關 [doctoral dissertation, National Taiwan University]. Airiti Library. https://doi.org/10.6342/NTU.2011.10341
- Chen, N. C., & Chang, Y. H. (2020). 案例報告：氟-18去氧葡萄糖正子斷層造影於抗合成酶抗體症候群的應用. 核子醫學暨分子影像雜誌, 33(1), 37-42. https://doi.org/10.6332/ANMMI.202003_33(1).0005
- 陳淑貞、李冠瑩、蔡惠予、吳志毅（2014）。Evaluation the Dose Length Product of (F18)FDG Whole-body PET/CT Study。臺灣醫事放射期刊，2(2)，13-24。https://doi.org/10.6717/JTMRT.201407_2(2).0002