Vibration induced liquefaction of soils is a hot-topic in geotechnical earthquake engineering. Building collapse and embankment burst caused by vibration or liquefaction are fatal for loss of lives and properties of human beings. A series of blasting tests including single blast and multiple underground blasts with millisecond delays were conducted on a large scale controlled field test site with saturated sand. The aim of this paper is to study the liquefaction mechanism produced by single shallow-buried detonations and multiple blasts with millisecond delays in saturated sand, and the influence factors on blast-induced liquefaction. Based on the results, the methods to produce a large area of liquefaction condition were determined. Stability of a refinforced concrete structure and a soil embankment were studied finally on the liquefaction site induced by multiple blasts with millisecond delays. The results can provide a reference to produce a large artificial liquefaction environment, and the basis for design and reinforcement of structures and soil- embankment on the sand foundation with a high water pressure.