Multi-layer composite substrate cutting technology is widely used in the glass panel cutting process in TFT-LCD and the wafer cutting process in semiconductor manufacturing. The demand for wearable devices has led to the development of high-strength multilayer composite substrates in the future, and the introduction of more advanced cutting techniques is imperative in order to build such new substrates. When laser is applied to cut multi-layer composite substrates, it has advantages of high stability in long-time processing; and due to the small dicing width, more chips can be yielded from a single wafer, thus increasing production efficiency. This article introduces laser dicing and stealth laser dicing technology, including hard and brittle materials and multi-layer composite substrate processing results. Finally, we introduce ITRI achievement in ultra-fast laser technology for cutting multi-layer composite substrates.