This dialogue features Professor Sandi W. Smith, who is a University Distinguished Professor in the Department of Communication at Michigan State University (MSU), a world-renowned professor of health communication, and an International Communication Association (ICA) fellow. Professor Smith first shares her views on how the COVID-19 pandemic has transformed health communication research. She also highlights the importance of transdisciplinary research in the post-pandemic era and how communication scholars could contribute their expertise to it. In the end, she offers suggestions to junior communication scholars for engaging in transdisciplinary research.