Non-Islet Cell Tumor-Induced Hypoglycemia in Type 2 Diabetes Mellitus - A Case Report and the Literature Review

Yi-Hsin Lin ； Jiun-Lu Lin ； Chao-Hung Wang ； Ming-Nan Chien

《Formosan Journal of Endocrinology and Metabolism》 4卷1期 (2013/06) Pp. 13-17

https://doi.org/10.6856/FJEM.201306_4(1).0004

摘要

Background. Although hypoglycemia is a common complication in patients with diabetes who received drug therapy, other causes of persistent hypoglycemia should be taken in consideration when oral anti-diabetic agents (OADs) or insulin are not prescribed. Paraneoplastic hypoglycemia or Doege-Potter syndrome is a rare cause of hypoglycemia in patients with solitary fibrous tumor. Methods. We report the clinical presentation, diagnosis, management, and outcome of a 74-year-old man with type 2 diabetes, severe hypoglycemia, and a huge lung mass. Results. The patient was presented to our hospital due to conscious change with hypoglycemia. Repeated episodes of symptomatic hypoglycemia were noted even after OADs were discontinued for more than five days. A huge lung mass over left lower lung was found by image studies. The pathologic diagnosis of the mass was malignant solitary fibrous tumor. Non-islet cell tumor-induced hypoglycemia was impressed. There was no more hypoglycemic episode after the tumor being surgically removed. Conclusion. Non-Islet Cell Tumor Hypoglycemia should not be ignored when unusual clinic course of recurrent hypoglycemia was detected even in patients with frank diabetes mellitus.

關鍵字

hypoglycemia ； non-islet cell tumor hypoglycemia ； solitary fibrous tumor ； paraneoplastic syndrome ； Doege-Potter syndrome