Postprandial Metabolic Response to a Diabetes Specific Formula in Subjects with Impaired Glucose Tolerance: A Pilot Study

Yu-Yi Lin ； Kuan-Hung Lin ； Chii-Min Hwu

《Formosan Journal of Endocrinology and Metabolism》 8卷1期 (2017/06) Pp. 14-23

https://doi.org/10.6856/FJEM.201706_8(1).0003

摘要

Background. Glucerna® SR is a diabetes-specific formula with low glycemic index. Data are needed to document whether Glucerna® SR is beneficial to subjects with impaired glucose tolerance (IGT). In the present study, we compared postprandial metabolic responses after using Glucerna® SR for breakfast in subjects with IGT and normal glucose tolerance (NGT). Methods. Eighteen subjects, 9 with NGT and 9 with IGT, were enrolled in the study to receive a single administration of 480 kcal Glucerna® SR (47.4% carbohydrates, 20.0% proteins and 32.6% fat) for breakfast. Blood samples were collected during the 4-hour meal test. Postprandial glucose, insulin and triglyceride responses were assessed. Results. There were significant differences between the two groups in postprandial glucose concentrations at 80, 100, 120, and 160 min after meal (all P ＜ 0.05). Total areas under the glucose response curves were greater in the IGT group compared with the NGT, before (P = 0.012) and after adjustments for age, sex and body mass index (P = 0.049). The overall insulin and triglyceride responses to the challenge of Glucerna® SR seemed to be comparable between the two groups. Conclusion. In the present study, we demonstrated that subjects with IGT and NGT had similar postprandial triglyceride response to a single administration of Glucerna® SR for breakfast. No significant between-group differences in insulin response were detected. Nonetheless, an acute challenge with Glucerna® SR would elicit a greater glycemic excursion in subjects with IGT than in NGT.

關鍵字

impaired glucose tolerance ； postprandial hyperglycemia ； Glucerna SR ； insulin ； triglycerides