Worsening Profiles of Cardiometabolic Risk Factors after Thionamide Treatment in Graves' Disease: A One-year Prospective Cohort Study

Chih-Chen Wang ； Ching-Han Lin ； Hao-Chang Hung ； Kai-Pi Cheng ； Ye-Fong Du ； Hung-Tsung Wu ； Horng-Yih Ou

《Formosan Journal of Endocrinology and Metabolism》 預刊文章 Pp. 1-9

https://doi.org/10.6856/FJEM.202012/PP.0001

摘要

Objective: Recent research demonstrated a significantly increased long-term cardiovascular risks in patients with treated Graves' disease. We aimed to comprehensively examine traditional cardiometabolic risk factors as well as the proportion of metabolic syndrome (MetS) and its components before and one year after thionamide treatment for Graves' disease. Method: This was a prospective observational study. Patients with newly diagnosed Graves' disease treated with thionamide were followed up to one year. Conventional cardiometabolic risk factors, as well as proportions of patients with MetS and its components were compared between baseline and one year after treatment. Result: A total of 97 patients (M/F: 29/68) were recruited. During the one-year follow-up, the body weight increased rapidly during the first 3 months, and was persistent thereafter in the first year, which was more severe in males than females. Waist circumference and body mass index also increased, whereas HDL-cholesterol decreased significantly after treatment in both genders. As for MetS components, we found significantly increased proportions of patients with abdominal obesity, hypertension, and hypertriglyceridemia after treatment. On the contrary, the percentage of hyperglycemia decreased significantly. Taken together, subjects with MetS increased accordingly from 6.3 % to 21.1 % (p = 0.017). Conclusion: We found that anthropometric measurements of central and general obesity increased significantly within one year after treatment. Furthermore, the proportion of patients with MetS and its components raised dramatically. Further studies will be needed to explore the contribution of MetS to the increased MACEs and diabetes in thionamide-treated Graves' disease.

關鍵字

Graves' disease ； thionamide ； cardiometabolic risk factors ； metabolic