Multifocal Insulinoma: A Case Report

Xin-Ning Ng ； Chun-Feng Wu ； Chii-Min Hwu

《Formosan Journal of Endocrinology and Metabolism》 13卷2期 (2022/12) Pp. 109-114

https://doi.org/10.6856/FJEM.202212_13(2).0015

摘要

Background: Insulinomas are the most frequent cause of hyperinsulinemic hypoglycemia. They are typically solitary benign neoplasms, which occur sporadically and can be cured with surgical resection. Multifocal insulinoma is rare and tend to be associated with multiple endocrine neoplasia (MEN1) syndrome or insulinomatosis. Methods: We present a case of multifocal insulinoma, manifesting as hyperinsulinemic hypoglycemia. Results: A 60-year-old woman presented with acute onset of lightheadedness, diaphoresis, and near fainting. Hypoglycemia along with elevated insulin and C-peptide level were demonstrated. Two pancreatic insulinomas were localized by computed tomography scan and endoscopic ultrasound. The patient underwent successful surgical resection with complete resolution of symptoms thereafter. Conclusion: Multicentric insulinomas should raise suspicion for MEN1 or insulinomatosis, which required lifelong active surveillance to evaluate subsequent development of disease recurrence.

關鍵字

insulinoma ； hyperinsulinism hypoglycemia ； insulinomatosis