濃縮蔓越莓緩解泌尿道發炎之研究

本研究背景：長年來蔓越莓（cranberry）一直被提倡用於緩解尿道感染（urinary tract infection, UTI）所使用的食品，因其富含抗氧化的多酚類物質複合原花青素（proanthocyanidins, PACs），特別是原花青素-A，對細菌具有抗黏附作用的特性，因此，蔓越莓對於UTI來說是有吸引力的，是非抗生素預防性選擇之一的品項，但科學界對其功效直至目前還是有所爭議的。研究發現女性在其一生中有50%的UTI風險，甚至有高達20－30%經歷了隨後的UTI復發現象。因此，本研究的目的是以濃縮蔓越莓進行緩解泌尿道發炎因子之研究，提出對尿道感染緩解與保健之建議，以藉由抑制一氧化氮（nitric oxide, NO）、介白素6（cytokine interleukin 6; IL-6）、腫瘤壞死因子-α（tumor necrosis factor; TNF-α），提出對三種抗發炎之研究。結果顯示，濃縮蔓越莓能顯著抑制細菌脂多醣（Lipopolysaccharide; LPS）所刺激的發炎NO反應抑制21.7%，但對於IL-6及TNF-α無抑制反應，同時濃縮蔓越莓對受測細胞並無細胞毒性之現象。雖然如此，本研究濃縮蔓越莓緩解泌尿道發炎之研究，僅為拋轉引玉的研究，期許提供農產事業及其相關生產鏈事業者，應用更多天然植物使用之思考與嘉惠消費者之提出，但仍需通過更多臨床實驗驗證，以及更多更高質量的研究，提供相關產業實務發展及學術參考之有效建議。

關鍵字

蔓越莓；尿道感染；抗發炎

並列摘要

Cranberry has been advocated for many years to alleviate the food used in urinary tract infection (UTI) because it is rich in antioxidant polyphenols combined with proanthocyanidins (PACs). Especially this ingredient, proanthocyanidin-A, has an anti-adhesive property against bacteria. Therefore, cranberry is attractive for UTI and is one of the non-antibiotic prophylactic options. But the scientific community has been controversial for its efficacy until now. Previous studies have found that women had a 50% UTI risk in their lifetime, and even up to 20-30% experienced subsequent UTI recurrence. Therefore, the purpose of this study was to investigate the effect of concentrated cranberry to relieve inflammation of the urinary tract. And provide suggestions for the relief and health care of urinary tract infections. That is, by inhibiting nitric oxide (NO), cytokine interleukin 6 (IL-6), and tumor necrosis factor-α (tumor necrosis factor; TNF-α), three anti-inflammatory drugs are proposed. The results showed that concentrated cranberry significantly inhibited the inhibition of inflammatory NO response stimulated by lipopolysaccharide (LPS) by 21.7%, but did not inhibit IL-6 and TNF-α, and concentrated cranberry on the cells tested. There is no cytotoxicity. Nevertheless, the study of concentrated cranberry to alleviate urinary tract inflammation in this study is only a study of turning jade. It is expected that the future agro-industry and related production chain enterprises can apply more natural plants to find anti-inflammatory foods to benefit consumers. Finally, this study still needs more clinical trials and more high-quality research to provide effective advice on relevant industry practice development and academic references.

並列關鍵字

cranberry ； urinary tract infection ； Anti-inflammatory

參考文獻

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濃縮蔓越莓緩解泌尿道發炎之研究

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