跑步機訓練於思覺失調個案心肺功能之成效：系統性回顧與統合分析

陳其嶸 ； 李宜玟 ； 郭毓馨 ； 陳姿廷 ； 林克忠

《台灣實證醫學學會會刊》 11卷2期 (2020/12) Pp. 21-30

https://doi.org/10.6864/EC.202012_11(2).0010

摘要

背景：思覺失調症有較高心血管及代謝疾病風險，跑步機運動可提供適當運動強度進而提升心肺功能，但該領域的相關研究仍較為有限。目標：本研究透過系統性回顧與統合分析的方式，探討跑步機訓練於思覺失調症個案心肺功能之成效。方法：本研究搜尋Cochrane、PubMed、Embase和華藝線上圖書館符合納入條件的文獻，搜尋日期至2020年7月。納入條件為跑步機訓練的隨機分派試驗。兩位獨立作者執行搜尋與萃取資料，透過Cochrane Risk of Bias進行品質評估。效果值則由最大攝氧量或峰值攝氧量值轉換為標準化平均差異（Standard mean difference, SMD）呈現。結果：本研究納入6篇隨機對照試驗，總計分析260位受試者。整合結果顯示跑步機訓練可顯著提升思覺失調症個案之心肺功能，SMD為0.49（95%CI: 0.20-0.79; p=0.001, I^2=26%），而最大攝氧量或峰值攝氧量較對照組平均高2.54 ml/kg/min（95%CI:1.52-3.57, p＜.001）。結論：跑步機訓練可顯著提升思覺失調症個案之心肺功能。然而，本研究樣本數仍少，未來仍需更多研究驗證之。

關鍵字

跑步機訓練 ； 思覺失調症 ； 心肺功能 ； 系統性文獻回顧與統合分析

並列摘要

Background: Patients with schizophrenia have higher risks of cardiovascular disease and metabolic disease. Treadmill exercise might provide adequate training, thus enhancing cardiorespiratory function. However, limited research on this topic is noted. Objective: The present systematic review and meta-analysis aimed to explore the efficacy of treadmill training on the cardiorespiratory function among patients with schizophrenia. Methods: Cochrane, PubMed, Embase, and airiti Library were systematically screened for eligible studies from inception to July 2020. Inclusion criteria is composed of randomized controlled trials (RCTs) focusing on the efficacy of tread-mill training. Two independent authors conducted the searching and extracted data. Cochrane Risk of bias was applied for quality assessment. Standard mean difference (SMD) was calculated as effect size on maximal oxygen uptake (VO_2max) or peak oxygen uptake (VO_2peak). Results: Six randomized controlled trials were identified in the present study with a total number of 260 participants. The results revealed that tread-mill training significantly improved cardiorespiratory functions of patients with schizophrenia (SMD=0.49, 95%CI: 0.20-0.79; p=0.001, I^2=26%). The VO_2max or VO_2peak of participants in treadmill group was higher in average 2.54 ml/kg/min (95%CI:1.52-3.57, p＜.001) compared to controls. Conclusions: Treadmill training could improve the cardiorespiratory function of patients with schizophrenia. However, the sample is relatively small in eligible studies. Further research is warranted.

並列關鍵字

Treadmill training ； Schizophrenia ； Cardiorespiratory function ； Systematic review and meta-analysis