Background: The aim of study was to investigate the influences of clinical variables on the quality of life (QoL) in incident peritoneal dialysis (PD) patients. Methods: The study was a prospectively case-controlled observational design. The patients equal or older than 18 years old who received PD at least 2 years were enrolled in the study. SF-36 health survey questionnaires were used to measure the QoL in the initiation of PD at the month of 0, 6 and 24. Comparable variables included epidemiology, social status, concomitant medical status and biochemical data. Results: Fifty-three incident patients (men 21/53, 39.6%) with the mean age of 48.3±12.6 year-old who received PD in our hospital were enrolled. The scores in all domains improved at 6th and 24^(th) month in comparison with the baseline scores. It showed significant in the domains of general health, pain, social functioning, energy/fatigue and role limitations due to physical health. After six months of PD therapy, unmarried subjects demonstrated higher scores in role limitations due to emotional problems(76.19vs47.75, p< 0.05), role limitations due to physical health(66.07vs37.16, p< 0.05)than married subjects but showed similar scores without significance at the 24^(th) month. Conclusions: Our study showed improvement of life quality during the two-year observational period. The influence of marriage status on QoL needs to be validated in the future research. The early intervention for individualized counseling is very important to improve their life quality.