This article discusses the etymon of four grammatical particles, including temporal suffix shǒu 手, the deictic particle ěr 爾, the pronoun plural markers nóng 儂 and the interrogative particle tǐ 底 in northern Wu and Min dialects as revealed by the historical documents. These four particles were used in the ancient Jiangdong 江東 dialect in Six Dynasties at one time. Among them, the front two came from the Koine earlier, and the other two were the southern elements at an initial stage. The author tries to show that the materials of northern Wu, especially Sunan Wu should play an indispensable role for the comparison between Wu and Min dialects. Besides, it is necessary for us to attach an importance to the study of the historical evolution of grammatical particles in Wu and Min.