Guangdong-Hong Kong-Macau Greater Bay Area holds important strategic position in the development of our country, also plays an absolute advantage in terms of education in colleges and universities. In recent years, "individual-oriented, heart-oriented" has become an important part of the national education policy, which leads the significant role of students' mental health work. This paper summarizes and compares the mental health work in colleges and universities in Guangdong, Hong Kong and Macao, and takes the work mode of University of Cambridge as a reference, proposes the challenges and future development of the mental health work in Guangdong-Hong Kong-Macao Greater Bay Area.