Inadvertent cannulation of the subclavian artery is a rare complication when choosing the subclavian vein as the site of central venous catheter insertion. Its management is based on patient factors and the site of arterial puncture. In this case report, inadvertent subclavian artery cannulation was successfully treated in an immunocompromised patient with coagulopathy by using a percutaneous vascular closure device after temporary balloon tamponade.